The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

Sri Fatmawati; Taslim Ersam; Kuniyoshi Shimizu

doi:10.1016/j.phymed.2014.11.001

The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

Phytomedicine. 2015 Jan 15;22(1):49-51. doi: 10.1016/j.phymed.2014.11.001. Epub 2014 Nov 20.

Authors

Sri Fatmawati¹, Taslim Ersam², Kuniyoshi Shimizu³

Affiliations

¹ Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Sepuluh Nopember, Kampus ITS-Sukolilo, Surabaya 60111, Indonesia. Electronic address: [email protected].
² Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Sepuluh Nopember, Kampus ITS-Sukolilo, Surabaya 60111, Indonesia.
³ Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.

PMID: 25636870
DOI: 10.1016/j.phymed.2014.11.001

Abstract

We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 µg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 µM.

Keywords: Aldose reductase; Diabetic complications; Garcinia mangostana; Mangostin; Xanthone.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehyde Reductase / antagonists & inhibitors*
Enzyme Inhibitors / pharmacology
Garcinia mangostana / chemistry*
Humans
Inhibitory Concentration 50
Molecular Structure
Plant Bark / chemistry
Plant Roots / chemistry
Xanthones / pharmacology*

Substances

3-isomangostin
Enzyme Inhibitors
Xanthones
Aldehyde Reductase