CD103+ γδ T cell large granular lymphocytosis in a patient with refractory celiac disease: a diagnostic enigma

Int J Hematol. 2015 Jun;101(6):603-7. doi: 10.1007/s12185-015-1736-x. Epub 2015 Jan 31.

Abstract

Indolent γδ T cell lymphomas/leukemias are rare and overlap with the morphological spectrum of large granular lymphocyte (LGL) leukemia. We report an extremely rare case of CD103(+) γδ T LGL leukemia in a patient with celiac disease who presented with refractory diarrhea. Whether the refractory diarrhea in our patient was a manifestation of LGL leukemia itself or whether the clonal LGL expansion is a manifestation of refractory celiac disease (RCD) remains an enigma. This report highlights the diagnostic difficulties and the need of consensus in categorizing clonal CD103(+) lymphocytosis in patients with RCD.

Publication types

  • Case Reports

MeSH terms

  • Antigens, CD / analysis*
  • Celiac Disease / complications*
  • Diarrhea / complications
  • Humans
  • Immunophenotyping
  • Integrin alpha Chains / analysis*
  • Leukemia, Large Granular Lymphocytic / complications*
  • Leukemia, Large Granular Lymphocytic / pathology
  • Male
  • Middle Aged
  • T-Lymphocytes / pathology*

Substances

  • Antigens, CD
  • Integrin alpha Chains
  • alpha E integrins