RIFM fragrance ingredient safety assessment, 2,6-Dimethyl-5-heptenal, CAS Registry Number 106-72-9

A M Api; D Belsito; S Bhatia; M Bruze; P Calow; M L Dagli; W Dekant; A D Fryer; L Kromidas; S La Cava; J F Lalko; A Lapczynski; D C Liebler; Y Miyachi; V T Politano; G Ritacco; D Salvito; J Shen; T W Schultz; I G Sipes; B Wall; D K Wilcox

doi:10.1016/j.fct.2015.01.007

RIFM fragrance ingredient safety assessment, 2,6-Dimethyl-5-heptenal, CAS Registry Number 106-72-9

Food Chem Toxicol. 2015 Aug:82 Suppl:S89-96. doi: 10.1016/j.fct.2015.01.007. Epub 2015 Jan 28.

Authors

A M Api¹, D Belsito², S Bhatia¹, M Bruze³, P Calow⁴, M L Dagli⁵, W Dekant⁶, A D Fryer⁷, L Kromidas⁸, S La Cava¹, J F Lalko¹, A Lapczynski¹, D C Liebler⁹, Y Miyachi¹⁰, V T Politano¹, G Ritacco¹, D Salvito¹, J Shen¹, T W Schultz¹¹, I G Sipes¹², B Wall¹, D K Wilcox¹

Affiliations

¹ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, United States.
² Member RIFM Expert Panel, Department of Dermatology, Columbia University Medical Center, 161 Fort Washington Ave., New York, NY 10032, United States.
³ Member RIFM Expert Panel, Department of Occupational & Environmental Dermatology, Malmo University Hospital, Sodra Forstadsgatan 101, Entrance 47, Malmo SE-20502, Sweden.
⁴ Member RIFM Expert Panel, 230 Whittier Research Center, University of Nebraska Lincoln, Lincoln, NE 68583-0857, United States.
⁵ Member RIFM Expert Panel, School of Veterinary Medicine and Animal Science, Department of Pathology, University of Sao Paulo, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo CEP 05508-900, Brazil.
⁶ Member RIFM Expert Panel, Department of Toxicology, University of Wuerzburg, Versbacher Str. 9, Würzburg 97078, Germany.
⁷ Member RIFM Expert Panel, Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, United States.
⁸ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, United States. Electronic address: [email protected].
⁹ Member RIFM Expert Panel, Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN 37232-0146, United States.
¹⁰ Member RIFM Expert Panel, Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
¹¹ Member RIFM Expert Panel, College of Veterinary Medicine, Department of Comparative Medicine, The University of Tennessee, 2407 River Dr., Knoxville, TN 37996-4500, United States.
¹² Member RIFM Expert Panel, Department of Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ 85724-5050, United States.

PMID: 25637761
DOI: 10.1016/j.fct.2015.01.007

No abstract available

Keywords: Environmental safety assessment; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergenicity; Repeated dose toxicity/developmental and reproductive toxicity; Skin Sensitization.

Publication types

Review

MeSH terms

Aldehydes / chemistry
Aldehydes / toxicity*
Animals
Consumer Product Safety*
DNA Damage / drug effects
Dose-Response Relationship, Drug
Endpoint Determination
Female
Humans
Male
Mice
No-Observed-Adverse-Effect Level
Perfume / chemistry
Perfume / toxicity*
Rats
Risk Assessment
Toxicity Tests

Substances

Aldehydes
Perfume
2,6-dimethyl-5-heptenal