[Treatment of hepatitis E virus infection]

Nassim Kamar; Lionel Rostaing; Laurent Alric; Jean-Marie Peron; Jacques Izopet

doi:10.1016/j.lpm.2014.10.011

[Treatment of hepatitis E virus infection]

Presse Med. 2015 Mar;44(3):339-42. doi: 10.1016/j.lpm.2014.10.011. Epub 2015 Jan 29.

[Article in French]

Authors

Nassim Kamar¹, Lionel Rostaing², Laurent Alric³, Jean-Marie Peron⁴, Jacques Izopet⁵

Affiliations

¹ CHU de Toulouse, hôpital Rangueil, département de néphrologie et transplantation d'organes, 31059 Toulouse cedex 9, France; Université Paul-Sabatier, 31062 Toulouse, France; Inserm U1043, IFR-BMT, hôpital Purpan, 31059 Toulouse cedex 9, France. Electronic address: [email protected].
² CHU de Toulouse, hôpital Rangueil, département de néphrologie et transplantation d'organes, 31059 Toulouse cedex 9, France; Université Paul-Sabatier, 31062 Toulouse, France; Inserm U1043, IFR-BMT, hôpital Purpan, 31059 Toulouse cedex 9, France.
³ Université Paul-Sabatier, 31062 Toulouse, France; CHU de Toulouse, hôpital Purpan, pôle digestif, service de médecine interne, 31059 Toulouse cedex 9, France.
⁴ Université Paul-Sabatier, 31062 Toulouse, France; CHU de Toulouse, hôpital Purpan, pôle digestif, service d'hépato-gastroentérologie, 31059 Toulouse cedex 9, France.
⁵ Université Paul-Sabatier, 31062 Toulouse, France; Inserm U1043, IFR-BMT, hôpital Purpan, 31059 Toulouse cedex 9, France; CHU de Toulouse, hôpital Purpan, laboratoire de virologie, institut fédératif de biologie, 31059 Toulouse cedex 9, France.

PMID: 25639626
DOI: 10.1016/j.lpm.2014.10.011

Abstract

The reduction of immunosuppressive therapy is the first-line therapeutic option in transplant-patients with chronic hepatitis E virus infection. Pegylated-interferon has been used for treating hepatitis E virus infection. Ribavirin alone is the treatment of choice of hepatitis E virus infection. Ribavirin is efficient for treating chronic hepatitis E in transplant patients, HIV patients, and hematology patients receiving or not chemotherapy. Ribavirin should be given to patients presenting hepatitis E virus associated extra-hepatic manifestations. The place of ribavirin therapy at acute phase is yet to be determined.

Publication types

English Abstract
Review

MeSH terms

Acute-Phase Reaction / therapy
Chronic Disease
HIV Infections / complications
HIV Infections / therapy
HIV-1
Hepatitis E / complications
Hepatitis E / therapy*
Hepatitis E virus*
Humans
Organ Transplantation