Hexamodal imaging with porphyrin-phospholipid-coated upconversion nanoparticles

Adv Mater. 2015 Mar 11;27(10):1785-90. doi: 10.1002/adma.201404739. Epub 2015 Jan 14.

Abstract

Hexamodal imaging using simple nanoparticles is demonstrated. Porphyrin-phospholipids are used to coat upconversion nanoparticles in order to generate a new biocompatible material. The nanoparticles are characterized in vitro and in vivo for imaging via fluorescence, upconversion, positron emission tomography, computed tomography, Cerenkov luminescence, and photoacoustic tomography.

Keywords: imaging; multimodal; nanoparticles; porphyrins; upconversion nanoparticles.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry
  • Contrast Media* / chemical synthesis
  • Contrast Media* / chemistry
  • Feasibility Studies
  • Lymph Nodes / diagnostic imaging
  • Lymph Nodes / metabolism
  • Materials Testing
  • Mice, Inbred BALB C
  • Multimodal Imaging / instrumentation
  • Muscle, Skeletal / diagnostic imaging
  • Muscle, Skeletal / metabolism
  • Nanoparticles* / chemistry
  • Optical Imaging / instrumentation
  • Phantoms, Imaging
  • Phospholipids* / chemistry
  • Photoacoustic Techniques / instrumentation
  • Porphyrins* / chemistry
  • Positron-Emission Tomography / instrumentation
  • Tomography, X-Ray Computed / instrumentation
  • Turkeys
  • Water
  • Whole Body Imaging / instrumentation

Substances

  • Biocompatible Materials
  • Contrast Media
  • Phospholipids
  • Porphyrins
  • Water