C-H functionalization of phenols using combined ruthenium and photoredox catalysis: in situ generation of the oxidant

Angew Chem Int Ed Engl. 2015 Feb 23;54(9):2801-5. doi: 10.1002/anie.201408891. Epub 2015 Jan 21.

Abstract

A combination of ruthenium and photoredox catalysis allowed the ortho olefination of phenols. Using visible light, the direct C-H functionalization of o-(2-pyridyl)phenols occurred, and diverse phenol ethers were obtained in good yields. The regeneration of the ruthenium catalyst was accomplished by a photoredox-catalyzed oxidative process.

Keywords: CH functionalization; alkenylation; photoredox catalysis; superoxide; visible light.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Oxidants / chemical synthesis*
  • Oxidants / chemistry
  • Oxidation-Reduction
  • Phenols / chemistry*
  • Photochemical Processes
  • Ruthenium / chemistry*

Substances

  • Organometallic Compounds
  • Oxidants
  • Phenols
  • Ruthenium