Hyperosmotic polydixylitol for crossing the blood brain barrier and efficient nucleic acid delivery

Chem Commun (Camb). 2015 Feb 28;51(17):3645-8. doi: 10.1039/c4cc09871d.

Abstract

Here, we introduce a polydixylitol based highly osmotic polymer that not only transmigrates the BBB by intra-arterial infusion of osmotic polyol but also triggers cellular uptake via modulation of caveolae mediated endocytosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood-Brain Barrier / drug effects
  • Blood-Brain Barrier / metabolism*
  • Caveolae / metabolism
  • Endocytosis / drug effects*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Molecular Structure
  • Nucleic Acids / metabolism*
  • Osmotic Pressure / drug effects*
  • Particle Size
  • Polymers / chemistry
  • Polymers / metabolism*
  • Polymers / pharmacology*
  • Surface Properties
  • Xylitol / analogs & derivatives*
  • Xylitol / chemistry
  • Xylitol / metabolism
  • Xylitol / pharmacology

Substances

  • Nucleic Acids
  • Polymers
  • Xylitol