Interleukin-18 is associated with protection against rhinovirus-induced colds and asthma exacerbations

Clin Infect Dis. 2015 May 15;60(10):1528-31. doi: 10.1093/cid/civ062. Epub 2015 Feb 2.

Abstract

Rhinoviruses cause the common cold and exacerbations of asthma. Animal models of infection have identified a protective role for interleukin-18 (IL-18). Following experimental rhinovirus infection, we observed increased respiratory symptoms in healthy and asthmatic subjects with low nasal and bronchial IL-18 levels.

Keywords: asthma; inflammasome; interleukin-18; rhinovirus infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asthma / immunology*
  • Asthma / pathology*
  • Asthma / virology
  • Common Cold / immunology*
  • Common Cold / pathology*
  • Common Cold / virology
  • Female
  • Humans
  • Interleukin-18 / analysis
  • Interleukin-18 / immunology*
  • Male
  • Middle Aged
  • Respiratory Mucosa / chemistry
  • Rhinovirus / immunology*

Substances

  • Interleukin-18