Abstract
We describe a simple quantitative bedside method for assessing the dopaminergic properties of new therapeutic agents, namely, by documenting their duration of action in patients with Parkinson's disease who exhibit "on-off" fluctuations. This model represents a form of human dopaminergic "bioassay".
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Antiparkinson Agents / pharmacology*
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Dopamine Agents / pharmacology*
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Drug Evaluation / methods
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Female
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Humans
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Male
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Middle Aged
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Oxazines / pharmacology*
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Parkinson Disease / drug therapy*
Substances
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Antiparkinson Agents
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Dopamine Agents
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Oxazines
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naxagolide