Strong and persistent correlation between baseline and follow-up HIV-DNA levels and residual viremia in a population of naïve patients with more than 4 years of effective antiretroviral therapy

Clin Microbiol Infect. 2015 Mar;21(3):288.e5-7. doi: 10.1016/j.cmi.2014.10.009. Epub 2014 Oct 29.

Abstract

In a longitudinal study on 181 naïve patients who responded to therapy (mean follow-up 4 years), high baseline human immunodeficiency virus (HIV)-RNA values correlated with high levels of cellular HIV-DNA at all time points (p < 0.0001, p 0.045, p 0.0055, and p 0.0025, respectively) and negatively correlated with undetectable residual viremia (URV; <2.5 copies/mL) at T1, T2, and T3 (p 0.026, p 0.0149, and p 0.0002, respectively). Baseline high HIV-DNA levels predicted the persistence of high values (p 0.0001) and negatively correlated with URV (p 0.0254, p 0.0481, and p 0.0085). These results suggest that baseline viral load, cellular HIV-DNA, and URV were strongly correlated over long-term follow-up of antiretroviral therapy responders.

Keywords: Cellular HIV-DNA; HIV-RNA; naïve patients; primary infection; residual viremia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antiretroviral Therapy, Highly Active*
  • CD4 Lymphocyte Count
  • DNA, Viral
  • Female
  • Follow-Up Studies
  • Genotype
  • HIV Infections / drug therapy*
  • HIV Infections / epidemiology
  • HIV Infections / virology*
  • HIV-1 / genetics*
  • Humans
  • Leukocytes, Mononuclear / virology*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Treatment Outcome
  • Viral Load*
  • Viremia*

Substances

  • DNA, Viral