Radiation dosimetry estimation of N-(2-[(18)F]fluoropropionyl)- L-glutamate based on the mice distribution data

Appl Radiat Isot. 2015 Apr:98:108-12. doi: 10.1016/j.apradiso.2015.01.026. Epub 2015 Jan 28.

Abstract

N-(2-[(18)F]fluoropropionyl)-l-glutamate([(18)F]FPGLU) was a recently developed potential amino acid tracer for tumor imaging with positron emission tomography-computer tomography (PET-CT). The absorbed and effective radiation doses resulting from the intravenous administration of [(18)F]FPGLU were estimated using biodistribution data from normal mice. The methodology recommended by Medical Internal Radiation Dose Committee (MIRD) was used to estimate the doses. The highest uptake of [(18)F]FPGLU was found in the kidneys, followed by the liver and lung. The kidneys were the organ received the highest absorbed dose, 58.4μGy/MBq, the brain received the lowest dose, 5.5μGy/MBq, and other organs received doses in the range of 8.3-11.9μGy/MBq. The effective dose was 17.0μSv/MBq. The data show that a 370MBq (10mCi) injection of [(18)F]FPGLU would lead to an estimated effective dose of 6.3mSv, which is within the accepted range of routine nuclear medicine investigations.

Keywords: Biodistribution; Dosimetry; N-(2-[(18)F]fluoropropionyl)-l-glutamate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Fluorine Radioisotopes*
  • Glutamates / therapeutic use*
  • Humans
  • Mice
  • Models, Animal
  • Positron-Emission Tomography / methods
  • Radiometry / methods
  • Radiopharmaceuticals*
  • Tissue Distribution

Substances

  • Fluorine Radioisotopes
  • Glutamates
  • N-(2-fluoropropionyl)glutamic acid
  • Radiopharmaceuticals