Abstract
Despite recent advances in the understanding of the biology of renal cell carcinoma (RCC), successful surgical treatment and implementation of novel‑targeted therapies, the prognosis for RCC patients remains poor. Late presentation, tumor heterogeneity and in particular the lack of molecular biomarkers for early detection, classification and the surveillance of RCC treatments are major obstacles. The increasing knowledge regarding the functional role of microRNAs (miRNAs) in pathophysiological processes may provide an important link to the identification of suitable therapeutic targets and diagnostic/prognostic biomarkers for RCC. The aim of this review was to provide new insight into the function of miRNAs in the pathogenesis of RCC and to emphasize their potential as diagnostic and prognostic markers, as well as therapeutic targets.
MeSH terms
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Adenylate Kinase / genetics
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Adenylate Kinase / physiology
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Biomarkers, Tumor
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Carcinoma, Renal Cell / diagnosis
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Carcinoma, Renal Cell / drug therapy
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Carcinoma, Renal Cell / genetics*
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Carcinoma, Renal Cell / physiopathology
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Chromosomal Instability
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DNA Methylation
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Gene Expression Regulation, Neoplastic* / drug effects
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Humans
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Hypoxia-Inducible Factor 1, alpha Subunit / genetics
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Hypoxia-Inducible Factor 1, alpha Subunit / physiology
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Kidney Neoplasms / diagnosis
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Kidney Neoplasms / drug therapy
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Kidney Neoplasms / genetics*
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Kidney Neoplasms / physiopathology
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MicroRNAs / blood
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MicroRNAs / genetics*
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MicroRNAs / therapeutic use
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Molecular Targeted Therapy
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Neoplasm Proteins / genetics
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Neoplasm Proteins / physiology
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Phosphatidylinositol 3-Kinases / genetics
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Phosphatidylinositol 3-Kinases / physiology
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Prognosis
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RNA, Messenger / genetics
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RNA, Neoplasm / blood
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RNA, Neoplasm / genetics*
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RNA, Neoplasm / therapeutic use
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Signal Transduction
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Von Hippel-Lindau Tumor Suppressor Protein / genetics
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Von Hippel-Lindau Tumor Suppressor Protein / physiology
Substances
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Biomarkers, Tumor
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HIF1A protein, human
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Hypoxia-Inducible Factor 1, alpha Subunit
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MicroRNAs
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Neoplasm Proteins
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RNA, Messenger
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RNA, Neoplasm
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Von Hippel-Lindau Tumor Suppressor Protein
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Phosphatidylinositol 3-Kinases
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Adenylate Kinase
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adenylate kinase 1