Abstract
Four new pregnane glycosides 1-4 were isolated from the ethanol extract of the stem of Gymnema sylvestre and named gymsylvestrosides A-D. Hydrolysis of compound 1 under the catalysis of Aspergilus niger β-glucosidase afforded compound 5 (gymsylvestroside E). Their structures were determined by spectroscopic methods such as HRESIMS, 1D and 2D NMR, as well as HMQC-TOCSY experiment. Compounds 1-4 were screened for Saccharomyces cerevisiae α-glucosidase inhibitory activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Glycoside Hydrolase Inhibitors* / chemistry
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Glycoside Hydrolase Inhibitors* / isolation & purification
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Glycosides* / chemistry
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Glycosides* / isolation & purification
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Gymnema sylvestre / chemistry*
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Pregnanes* / chemistry
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Pregnanes* / isolation & purification
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Saccharomyces cerevisiae / enzymology*
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Saccharomyces cerevisiae Proteins* / antagonists & inhibitors
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Saccharomyces cerevisiae Proteins* / chemistry
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alpha-Glucosidases / chemistry*
Substances
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Glycoside Hydrolase Inhibitors
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Glycosides
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Pregnanes
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Saccharomyces cerevisiae Proteins
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alpha-Glucosidases