MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas

Abdirisak Ahmed Haji Omar; Caj Haglund; Susanna Virolainen; Valtteri Häyry; Timo Atula; Risto Kontio; Tuula Salo; Timo Sorsa; Jaana Hagström

doi:10.1016/j.oooo.2014.12.019

MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas

Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Apr;119(4):459-67. doi: 10.1016/j.oooo.2014.12.019. Epub 2015 Jan 6.

Authors

Abdirisak Ahmed Haji Omar¹, Caj Haglund², Susanna Virolainen³, Valtteri Häyry⁴, Timo Atula⁴, Risto Kontio⁵, Tuula Salo⁶, Timo Sorsa⁷, Jaana Hagström⁸

Affiliations

¹ Institute of Dentistry, University of Helsinki, Helsinki, Finland. Electronic address: [email protected].
² Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland; Research Programs Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland.
³ Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland.
⁴ Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland.
⁵ Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland.
⁶ Institute of Dentistry, University of Helsinki, Helsinki, Finland; Medical Research Center Oulu, University of Oulu, Oulu, Finland.
⁷ Institute of Dentistry, University of Helsinki, Helsinki, Finland; Division of Periodontology, Department of Dental Medicine, Karolinska Institute, Huddinge, Sweden.
⁸ Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland; Department of Oral Pathology, Institute of Dentistry, University of Helsinki, Helsinki, Finland.

PMID: 25697929
DOI: 10.1016/j.oooo.2014.12.019

Abstract

Objectives: Oral squamous cell carcinoma (OSCC) and cutaneous squamous cell carcinoma (CSCC) are epithelial neoplasms, of which OSCC has a worse prognosis. Matrix metalloproteinases (MMPs) are involved in the initiation, invasion, metastasis, and defense of cancer. This study aimed to compare differences in MMP expression in these cancers.

Study design: Sixty-one patients with early-stage (T1-T2 N0 M0) cancers, of which 36 were OSCC and 25 CSCC, were enrolled into this study. Immunohistochemical staining was performed with MMP-7, MMP-8, and MMP-9 antibodies.

Results: MMP-7 expression was stronger in OSCC than in CSCC, mainly in the invasive front. MMP-8 was absent and MMP-9 was mildly expressed in OSCC and CSCC cells. However, MMP-8 and MMP-9 were positive in peritumoral inflammatory cells in both cancers. In addition, MMP-7, MMP-8, and MMP-9 were not associated with the overall survival of patients with OSCC and CSCC patients.

Conclusions: The increased expression of MMP-7 in the invasive front may partly explain the aggressiveness of OSCC.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Biomarkers, Tumor / metabolism
Carcinoma, Squamous Cell / enzymology*
Female
Humans
Immunohistochemistry
Male
Matrix Metalloproteinase 7 / metabolism*
Matrix Metalloproteinase 8 / metabolism*
Matrix Metalloproteinase 9 / metabolism*
Middle Aged
Mouth Neoplasms / enzymology*
Skin Neoplasms / enzymology*

Substances

Biomarkers, Tumor
Matrix Metalloproteinase 7
Matrix Metalloproteinase 8
Matrix Metalloproteinase 9