BamHI and SacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people. Evidence for a major polymorphism

N Ghanem; M Bensmana; J M Dugoujon; J Constans; M P Lefranc; G Lefranc

doi:10.1007/BF00274144

BamHI and SacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people. Evidence for a major polymorphism

Hum Genet. 1989 Aug;83(1):37-44. doi: 10.1007/BF00274144.

Authors

N Ghanem¹, M Bensmana, J M Dugoujon, J Constans, M P Lefranc, G Lefranc

Affiliation

¹ Laboratoire d'Immunogénétique, URA CNRS 1191, Université des Sciences et Techniques du Languedoc, Montpellier, France.

PMID: 2570016
DOI: 10.1007/BF00274144

Abstract

In this paper, we extend the study of the IGHG gene RFLPs in black African persons and in some other individuals characterized by a Negroid admixture. We demonstrate a polymorphism that is much more important in black Africans, than in Caucasoids, mainly for the IGHG3 and G1 genes, the most 5' members of the IGHG multigene family. These genes encode for the IgG3 and IgG1 subclasses, which are of crucial biological importance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Black People / genetics*
Deoxyribonuclease BamHI
Ethnicity
Gene Frequency
Genes, Immunoglobulin
Humans
Immunoglobulin Gm Allotypes / genetics*
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length*

Substances

Immunoglobulin Gm Allotypes
Deoxyribonuclease BamHI