Abstract
With the successful development of meningococcal vaccines against other serogroups, disease caused by Neisseria meningitidis serogroup B now accounts for a disproportionate frequency compared with other serogroups, particularly in the US and Europe. Infants and adolescents bear the highest incidence of disease, which typically manifests as meningitis and septicemia. This vaccine profile article examines a bivalent factor H binding protein (fHbp; also known as LP2086) vaccine that has now been approved by the US FDA for use in 10- to 25-year olds. The manufacturer has shelved plans for further investigation of its use in infants because of high rates of fever in Phase I and II trials in that age group.
Keywords:
MenB vaccine; Trumenba; fHbp; meningococcal vaccine; rLP2086.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Antigens, Bacterial / immunology*
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Bacterial Proteins / immunology*
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Child
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Child, Preschool
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Clinical Trials, Phase I as Topic
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Clinical Trials, Phase II as Topic
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Drug Approval
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Europe / epidemiology
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Fever / chemically induced
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Humans
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Infant
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Meningococcal Infections / epidemiology
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Meningococcal Infections / microbiology
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Meningococcal Infections / prevention & control*
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Meningococcal Vaccines / adverse effects*
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Meningococcal Vaccines / immunology*
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Middle Aged
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Neisseria meningitidis, Serogroup B / immunology*
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Sepsis / epidemiology
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Sepsis / microbiology
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Sepsis / prevention & control*
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United States / epidemiology
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Young Adult
Substances
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Antigens, Bacterial
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Bacterial Proteins
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Meningococcal Vaccines
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factor H-binding protein, Neisseria meningitidis