PfRH5 as a candidate vaccine for Plasmodium falciparum malaria

Damien R Drew; James G Beeson

doi:10.1016/j.pt.2015.02.001

PfRH5 as a candidate vaccine for Plasmodium falciparum malaria

Trends Parasitol. 2015 Mar;31(3):87-8. doi: 10.1016/j.pt.2015.02.001. Epub 2015 Feb 19.

Authors

Damien R Drew¹, James G Beeson²

Affiliations

¹ Burnet Institute, 85 Commercial Road, Melbourne, Victoria, Australia.
² Burnet Institute, 85 Commercial Road, Melbourne, Victoria, Australia; Department of Microbiology, Monash University, Victoria, Australia. Electronic address: [email protected].

PMID: 25704640
DOI: 10.1016/j.pt.2015.02.001

Abstract

PfRH5 has recently emerged as a strong vaccine candidate for Plasmodium falciparum malaria. Antibodies inhibit invasion of erythrocytes by merozoites and blood-stage replication, and PfRH5 is a significant target of acquired human immunity. Recent studies have shown protective efficacy of PfRH5 vaccines in a non-human primate model of malaria.

Keywords: PfRH5; Plasmodium falciparum; invasion; malaria; vaccines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Protozoan / blood
Carrier Proteins / immunology*
Humans
Malaria, Falciparum / blood
Malaria, Falciparum / prevention & control*
Primates
Protozoan Vaccines / genetics*
Protozoan Vaccines / immunology

Substances

Antibodies, Protozoan
Carrier Proteins
Protozoan Vaccines
RH5 protein, Plasmodium falciparum