Antigen processing: current issues, exceptional cases (Thy 1 alloantigen, MHC class-II-restricted cytolytic T cells), and implications for vaccine development

B M Chain; N A Mitchison; T J Mitchison; D H Davies; J Marcinkiewicz

doi:10.1016/0896-8411(89)90116-9

Antigen processing: current issues, exceptional cases (Thy 1 alloantigen, MHC class-II-restricted cytolytic T cells), and implications for vaccine development

J Autoimmun. 1989 Jun:2 Suppl:45-53. doi: 10.1016/0896-8411(89)90116-9.

Authors

B M Chain¹, N A Mitchison, T J Mitchison, D H Davies, J Marcinkiewicz

Affiliation

¹ Department of Biology, University College London, UK.

PMID: 2570591
DOI: 10.1016/0896-8411(89)90116-9

Abstract

A dogmatic view of antigen processing is presented in outline, followed by a survey of unresolved issues in the subject. The activity of Thy 1 as an alloantigen, and allospecific MHC Class-II-restricted cytolytic T cells offer examples of exceptional cases of antigen presentation. Implications for the design of vaccines are drawn.

Publication types

Review

MeSH terms

Animals
Antigen-Presenting Cells / immunology
Antigens*
Antigens, Surface
Biological Transport, Active
Histocompatibility Antigens Class II
Humans
T-Lymphocytes, Cytotoxic / immunology
Thy-1 Antigens
Vaccines / isolation & purification

Substances

Antigens
Antigens, Surface
Histocompatibility Antigens Class II
Thy-1 Antigens
Vaccines