[Molecular and cellular mechanisms of depression. Role of glucocorticoids, cytokines, neurotransmitters, and trophic factors in genesis of depressive disorders]

Usp Fiziol Nauk. 2014 Apr-Jun;45(2):3-19.
[Article in Russian]

Abstract

Here we review modern data on appearance and maintenance of depression at different levels of the body. We discuss a role of impairments of emotional and motivation mechanisms of adaptive behavior in genesis of depression. We demonstate an interaction of stress response and neuroinflammatory processes in pathogenesis of depression and analyze the effects of these molecular cascades on neurotrophic support of the central mechanisms of memory and neurogenesis.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Psychological*
  • Animals
  • Biogenic Monoamines / metabolism
  • Cognition / physiology
  • Cytokines / immunology*
  • Depression / etiology*
  • Depression / immunology
  • Depression / metabolism
  • Depression / psychology
  • Glucocorticoids / metabolism*
  • Humans
  • Memory / physiology
  • Nerve Growth Factors / metabolism*
  • Neuroimmunomodulation
  • Neuronal Plasticity
  • Synaptic Transmission*

Substances

  • Biogenic Monoamines
  • Cytokines
  • Glucocorticoids
  • Nerve Growth Factors