Abstract
Copper-catalyzed ortho-halogenation of C(sp(2))-H bonds directed by a PIP directing group with NXS (X = Cl, Br, I) has been developed. The reaction is scalable and tolerates a broad range of functional groups and heteroarenes, providing an efficient access to halogenated arenes and heteroarenes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzene Derivatives / chemistry*
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Catalysis
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Copper / chemistry*
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Halogenation
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Heterocyclic Compounds / chemistry*
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Hydrocarbons, Halogenated / chemical synthesis*
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Hydrocarbons, Halogenated / chemistry
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Molecular Structure
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Propylamines / chemistry*
Substances
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Benzene Derivatives
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Heterocyclic Compounds
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Hydrocarbons, Halogenated
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Propylamines
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Copper