International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors

Jörg Hamann; Gabriela Aust; Demet Araç; Felix B Engel; Caroline Formstone; Robert Fredriksson; Randy A Hall; Breanne L Harty; Christiane Kirchhoff; Barbara Knapp; Arunkumar Krishnan; Ines Liebscher; Hsi-Hsien Lin; David C Martinelli; Kelly R Monk; Miriam C Peeters; Xianhua Piao; Simone Prömel; Torsten Schöneberg; Thue W Schwartz; Kathleen Singer; Martin Stacey; Yuri A Ushkaryov; Mario Vallon; Uwe Wolfrum; Mathew W Wright; Lei Xu; Tobias Langenhan; Helgi B Schiöth

doi:10.1124/pr.114.009647

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors

Pharmacol Rev. 2015;67(2):338-67. doi: 10.1124/pr.114.009647.

Authors

Jörg Hamann¹, Gabriela Aust¹, Demet Araç¹, Felix B Engel¹, Caroline Formstone¹, Robert Fredriksson¹, Randy A Hall¹, Breanne L Harty¹, Christiane Kirchhoff¹, Barbara Knapp¹, Arunkumar Krishnan¹, Ines Liebscher¹, Hsi-Hsien Lin¹, David C Martinelli¹, Kelly R Monk¹, Miriam C Peeters¹, Xianhua Piao¹, Simone Prömel¹, Torsten Schöneberg¹, Thue W Schwartz¹, Kathleen Singer¹, Martin Stacey¹, Yuri A Ushkaryov¹, Mario Vallon¹, Uwe Wolfrum¹, Mathew W Wright¹, Lei Xu¹, Tobias Langenhan¹, Helgi B Schiöth¹

Affiliation

¹ Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (J.H.); Department of Surgery, Research Laboratories (G.A), and Institute of Biochemistry (I.L., S.P., T.S.), Medical Faculty, University of Leipzig, Leipzig, Germany; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois (D.A.); Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (F.B.E.); MRC Centre for Developmental Neurobiology, King's College London, London, United Kingdom (C.F.); Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden (R.F., A.K., H.B.S.); Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (R.A.H.); Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri (B.L.H., K.R.M.); Department for Andrology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (C.K.); Cell and Matrix Biology, Institute of Zoology, Johannes Gutenberg University Mainz, Mainz, Germany (B.K., U.W.); Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan (H.-H.L.); Department of Molecular and Cellular Physiology (D.C.M.) and Division of Hematology (M.V.), Stanford University School of Medicine, Stanford, California; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands (M.C.P.); Department of Neuroscience and Pharmacology and Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark (M.C.P., T.W.S.); Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts (X.P., K.S.); Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom (M.S.); Medway School of Pharmacy, University of Kent, Chatham, United Kingdom (Y.A.U.); HUGO Gene Nomen

Abstract

The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Adhesion
Cell Adhesion Molecules / chemistry
Cell Adhesion Molecules / metabolism*
Cell Membrane / enzymology
Cell Membrane / metabolism
Cell Movement
Cyclic AMP / physiology*
Humans
International Agencies
Ligands
Models, Molecular*
Pharmacology / trends
Pharmacology, Clinical / trends
Protein Isoforms / agonists
Protein Isoforms / chemistry
Protein Isoforms / classification
Protein Isoforms / metabolism
Receptors, G-Protein-Coupled / agonists
Receptors, G-Protein-Coupled / chemistry
Receptors, G-Protein-Coupled / classification
Receptors, G-Protein-Coupled / metabolism*
Second Messenger Systems*
Signal Transduction
Societies, Scientific
Terminology as Topic

Substances

Cell Adhesion Molecules
Ligands
Protein Isoforms
Receptors, G-Protein-Coupled
Cyclic AMP

Abstract

Publication types

MeSH terms

Substances

Grants and funding