Localization of a human brain sodium channel gene (SCN2A) to chromosome 2

Genomics. 1989 Aug;5(2):204-8. doi: 10.1016/0888-7543(89)90047-5.

Abstract

A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the alpha-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blotting, Southern
  • Chromosome Banding
  • Chromosome Mapping
  • Chromosomes, Human, Pair 2 / ultrastructure*
  • Cricetinae
  • DNA Probes
  • Humans
  • Hybrid Cells
  • Male
  • Mice
  • Polymorphism, Restriction Fragment Length
  • Restriction Mapping
  • Sodium Channels*

Substances

  • DNA Probes
  • Sodium Channels