Serum anti-tissue transglutaminase antibodies detected during febrile illness may not be produced by the intestinal mucosa

Luigina De Leo; Sara Quaglia; Fabiana Ziberna; Serena Vatta; Stefano Martelossi; Massimo Maschio; Tarcisio Not

doi:10.1016/j.jpeds.2014.12.005

Serum anti-tissue transglutaminase antibodies detected during febrile illness may not be produced by the intestinal mucosa

J Pediatr. 2015 Mar;166(3):761-3. doi: 10.1016/j.jpeds.2014.12.005.

Authors

Luigina De Leo¹, Sara Quaglia¹, Fabiana Ziberna¹, Serena Vatta¹, Stefano Martelossi¹, Massimo Maschio¹, Tarcisio Not²

Affiliations

¹ Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
² Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy; University of Trieste, Trieste, Italy. Electronic address: [email protected].

PMID: 25722272
DOI: 10.1016/j.jpeds.2014.12.005

Abstract

Anti-transglutaminase antibodies are the diagnostic marker of celiac disease, and are considered to be synthesized only by intestinal B-lymphocytes. During an infectious disease, these antibodies are transiently detected in serum. We show that these infection-triggered antibodies may not originate in the intestinal mucosa and are not an indication of celiac disease.

Trial registration: ClinicalTrials.gov NCT00677495.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Autoantibodies / blood*
Celiac Disease / diagnosis
Celiac Disease / enzymology*
Celiac Disease / immunology
Child, Preschool
Diagnosis, Differential
Enzyme-Linked Immunosorbent Assay
Female
GTP-Binding Proteins / blood
GTP-Binding Proteins / immunology*
Humans
Intestinal Mucosa / immunology*
Intestinal Mucosa / pathology
Male
Protein Glutamine gamma Glutamyltransferase 2
Transglutaminases / blood
Transglutaminases / immunology*

Substances

Autoantibodies
Protein Glutamine gamma Glutamyltransferase 2
Transglutaminases
GTP-Binding Proteins

Associated data

ClinicalTrials.gov/NCT00677495