Superselective intra-arterial chemotherapy for advanced retinoblastoma complicated by metastatic disease

Anu A Mathew; Nisha Sachdev; Sandra E Staffieri; John D McKenzie; James E Elder

doi:10.1016/j.jaapos.2014.08.013

Superselective intra-arterial chemotherapy for advanced retinoblastoma complicated by metastatic disease

J AAPOS. 2015 Feb;19(1):72-4. doi: 10.1016/j.jaapos.2014.08.013.

Authors

Anu A Mathew¹, Nisha Sachdev², Sandra E Staffieri³, John D McKenzie², James E Elder⁴

Affiliations

¹ Department of Ophthalmology, Royal Children's Hospital, Melbourne, Victoria, Australia. Electronic address: [email protected].
² Department of Ophthalmology, Royal Children's Hospital, Melbourne, Victoria, Australia.
³ Department of Ophthalmology, Royal Children's Hospital, Melbourne, Victoria, Australia; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Victoria, Australia.
⁴ Department of Ophthalmology, Royal Children's Hospital, Melbourne, Victoria, Australia; Department of Paediatrics, University of Melbourne, Victoria, Australia.

PMID: 25727592
DOI: 10.1016/j.jaapos.2014.08.013

Abstract

We present a case of a child with unilateral group E retinoblastoma (according to the International Classification of Retinoblastoma) who received superselective intra-arterial chemotherapy as primary therapy. Although the tumor showed signs of regression, the patient developed orbital metastases requiring surgical excision and chemotherapy. Eventually the affected eye progressed to total retinal detachment and required enucleation.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Carboplatin / administration & dosage
Child, Preschool
Cyclophosphamide / administration & dosage
Etoposide / administration & dosage
Eye Enucleation
Humans
Infusions, Intra-Arterial
Magnetic Resonance Imaging
Male
Microscopy, Acoustic
Orbital Neoplasms / drug therapy*
Orbital Neoplasms / secondary
Orbital Neoplasms / surgery
Retinal Neoplasms / drug therapy*
Retinal Neoplasms / pathology
Retinal Neoplasms / surgery
Retinoblastoma / drug therapy*
Retinoblastoma / secondary
Retinoblastoma / surgery
Vincristine / administration & dosage

Substances

Vincristine
Etoposide
Cyclophosphamide
Carboplatin

Supplementary concepts

CEV regimen