Bitten by a bug or a bag? Transfusion-transmitted dengue: a rare complication in the bleeding surgical patient

Transfusion. 2015 Jul;55(7):1655-61. doi: 10.1111/trf.13054. Epub 2015 Feb 26.

Abstract

Background: Blood-borne infections remain a risk of blood transfusions. While routine screening of donated blood products has greatly reduced the risk of human immunodeficiency virus, hepatitis B, and hepatitis C transmission, arboviruses such as dengue, chikungunya, and the West Nile virus remain significant risks especially during outbreaks.

Case report: We report a rare case of dengue documented to be acquired through a blood transfusion, which resulted in severe thrombocytopenia prolonging admission in hospital in a neurosurgical patient.

Results: The donor of one of the units of red blood cells presented with dengue fever 2 days after donating. Sanger sequencing confirmed DENV-2 (dengue virus, Serotype 2) in both the donor and the patient samples and showed 100% nucleotide sequence identity between the two viruses, confirming transfusion-transmitted dengue infection.

Conclusion: This case highlights the importance of arboviral screening of donor blood, especially for populations in endemic areas during outbreaks.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blood Loss, Surgical / prevention & control*
  • Dengue Virus* / genetics
  • Dengue Virus* / isolation & purification
  • Dengue* / blood
  • Dengue* / transmission
  • Erythrocyte Transfusion*
  • Erythrocytes / virology*
  • Female
  • Humans
  • Neurosurgical Procedures / adverse effects*