Disseminated Mycobacterium gordonae and Mycobacterium mantenii infection with elevated anti-IFN-γ neutralizing autoantibodies

Isano Hase; Kozo Morimoto; Takuro Sakagami; Yuko Kazumi; Yoshiki Ishii; Jakko van Ingen

doi:10.1016/j.jiac.2015.02.003

Disseminated Mycobacterium gordonae and Mycobacterium mantenii infection with elevated anti-IFN-γ neutralizing autoantibodies

J Infect Chemother. 2015 Jun;21(6):468-72. doi: 10.1016/j.jiac.2015.02.003. Epub 2015 Feb 12.

Authors

Isano Hase¹, Kozo Morimoto², Takuro Sakagami³, Yuko Kazumi⁴, Yoshiki Ishii⁵, Jakko van Ingen⁶

Affiliations

¹ Department of Respiratory Disease, Southern Tohoku General Hospital, 7-115 Yatsuyamada, Koriyama-shi, Fukushima 963-8563, Japan; Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan. Electronic address: [email protected].
² Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose-shi, Tokyo 204-0022, Japan.
³ Division of Respiratory Medicine and Infectious Disease, Department of Homeostatic Regulation and Development, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Niigata-shi, Niigata 951-8510, Japan.
⁴ Molecular Epidemiology and Genetic Identification Division, Department of Mycobacteria References and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose-shi, Tokyo 204-8533, Japan.
⁵ Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan.
⁶ Department of Medical Microbiology, Radboud University Medical Center, P.O. Box 9101, 6500HB Nijmegen, The Netherlands.

PMID: 25735882
DOI: 10.1016/j.jiac.2015.02.003

Abstract

A case of disseminated nontuberculous mycobacteria(l) (NTM) infection in a patient with positive neutralizing anti-interferon-γ (IFN-γ) autoantibodies involving bone, bronchus, systemic lymph nodes, and skin is reported. The causative NTMs were two different strains: Mycobacterium gordonae, which rarely causes true disease, and Mycobacterium mantenii, which is extremely rare. Anti-mycobacterial treatment successfully ameliorated all disseminated lesions. Although the concentration of anti-IFN-γ autoantibodies increased during the pre-treatment period, it gradually decreased after anti-mycobacterial treatment was started.

Keywords: Anti-IFN-γ neutralizing autoantibodies; Disseminated nontuberculous mycobacterium infection; Mycobacterium gordonae; Mycobacterium mantenii.

Publication types

Case Reports

MeSH terms

Aged
Antibodies, Neutralizing / immunology*
Autoantibodies / immunology*
Humans
Interferon-gamma / immunology*
Male
Mycobacterium Infections, Nontuberculous / immunology*
Nontuberculous Mycobacteria / immunology*

Substances

Antibodies, Neutralizing
Autoantibodies
Interferon-gamma