A coumarin lignanoid from the stems of Kadsura heteroclita

Wei Su; Jianping Zhao; Min Yang; Hui-Wen Yan; Tao Pang; Sheng-Huang Chen; Hui-Yong Huang; Shui-Han Zhang; Xiao-Chi Ma; De-An Guo; Ikhlas A Khan; Wei Wang

doi:10.1016/j.bmcl.2015.02.022

A coumarin lignanoid from the stems of Kadsura heteroclita

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1506-8. doi: 10.1016/j.bmcl.2015.02.022. Epub 2015 Feb 17.

Authors

Wei Su¹, Jianping Zhao², Min Yang³, Hui-Wen Yan⁴, Tao Pang⁵, Sheng-Huang Chen¹, Hui-Yong Huang¹, Shui-Han Zhang¹, Xiao-Chi Ma⁶, De-An Guo³, Ikhlas A Khan², Wei Wang⁷

Affiliations

¹ TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
² National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, MS 38677, USA.
³ Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, CAS, Shanghai 201203, China.
⁴ School of Life Sciences, Central South University, Changsha 410013, China.
⁵ State Key Laboratory of Natural Medicines, New Drug Screening Center, China Pharmaceutical University, Nanjing 210009, China.
⁶ College of Pharmacy, Dalian Medical University, Dalian 116044, China.
⁷ TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China. Electronic address: [email protected].

PMID: 25736995
DOI: 10.1016/j.bmcl.2015.02.022

Abstract

Coumarinlignan (1), possessing a unique coumarin-containing lignan skeleton, was isolated from the stems of Kadsura heteroclita. Its structure and absolute configuration were determined by spectroscopic techniques, especially 2D NMR and X-ray crystallographic data analyses. The proposed biosynthetic pathway is discussed. This new compound showed good anti-HBV activity against HBeAg and HBsAg, and moderate anti-fibrotic and neuroprotective activities.

Keywords: Anti-HBV activity; Coumarin lignoid; Coumarinlignan; Kadsura heteroclita.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiviral Agents / chemistry
Antiviral Agents / isolation & purification
Antiviral Agents / pharmacology*
Cell Line
Coumarins / chemistry
Coumarins / isolation & purification
Coumarins / pharmacology*
Crystallography, X-Ray
Dose-Response Relationship, Drug
Hepatitis B Surface Antigens / drug effects
Hepatitis B e Antigens / drug effects
Hepatitis B virus / drug effects*
Humans
Kadsura / chemistry*
Lignans / chemistry
Lignans / isolation & purification
Lignans / pharmacology*
Microbial Sensitivity Tests
Models, Molecular
Molecular Structure
Neurons / drug effects
Neuroprotective Agents / chemistry
Neuroprotective Agents / isolation & purification
Neuroprotective Agents / pharmacology*
PC12 Cells
Plant Stems / chemistry*
Rats
Structure-Activity Relationship

Substances

Antiviral Agents
Coumarins
Hepatitis B Surface Antigens
Hepatitis B e Antigens
Lignans
Neuroprotective Agents
coumarinlignan