Abstract
To evaluate seasonal trivalent inactivated influenza vaccine effectiveness (VE) in Scotland, we performed a Scotland-wide linkage of patient-level primary care, hospital and virological swab data from 3,323 swabs (pooling data over nine influenza seasons: 2000/01 to 2008/09). We estimated the VE for reducing realtime RT-PCR-confirmed influenza using a test-negative study design. Vaccination was associated with a 57% (95% confidence interval (CI): 31–73) reduction in the risk of PCR-confirmed influenza. VE was 60% (95% CI:22–79) for patients younger than 65 years and clinically at risk of serious complications from influenza, and 19% (95% CI: −104 to 68) for any individual 65 years and older. Vaccination was associated with substantial, sustained reductions in laboratory-confirmed influenza in the general population and younger patients in clinical at-risk groups.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Child
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Child, Preschool
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Disease Outbreaks / prevention & control*
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Female
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Humans
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Infant
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Infant, Newborn
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Influenza A virus / genetics
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Influenza A virus / immunology
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Influenza A virus / isolation & purification*
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Influenza Vaccines / administration & dosage*
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Influenza Vaccines / immunology*
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Influenza, Human / diagnosis
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Influenza, Human / epidemiology*
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Influenza, Human / prevention & control*
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Influenza, Human / virology
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Logistic Models
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Male
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Middle Aged
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Primary Health Care
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Reverse Transcriptase Polymerase Chain Reaction
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Scotland / epidemiology
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Seasons
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Sentinel Surveillance
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Sequence Analysis, DNA
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Time Factors
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Treatment Outcome
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Vaccination / statistics & numerical data
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Vaccines, Inactivated / administration & dosage
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Vaccines, Inactivated / immunology
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Young Adult
Substances
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Influenza Vaccines
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Vaccines, Inactivated