Trivalent inactivated seasonal influenza vaccine effectiveness for the prevention of laboratory-confirmed influenza in a Scottish population 2000 to 2009

Euro Surveill. 2015 Feb 26;20(8):21043. doi: 10.2807/1560-7917.es2015.20.8.21043.

Abstract

To evaluate seasonal trivalent inactivated influenza vaccine effectiveness (VE) in Scotland, we performed a Scotland-wide linkage of patient-level primary care, hospital and virological swab data from 3,323 swabs (pooling data over nine influenza seasons: 2000/01 to 2008/09). We estimated the VE for reducing realtime RT-PCR-confirmed influenza using a test-negative study design. Vaccination was associated with a 57% (95% confidence interval (CI): 31–73) reduction in the risk of PCR-confirmed influenza. VE was 60% (95% CI:22–79) for patients younger than 65 years and clinically at risk of serious complications from influenza, and 19% (95% CI: −104 to 68) for any individual 65 years and older. Vaccination was associated with substantial, sustained reductions in laboratory-confirmed influenza in the general population and younger patients in clinical at-risk groups.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Disease Outbreaks / prevention & control*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Influenza A virus / genetics
  • Influenza A virus / immunology
  • Influenza A virus / isolation & purification*
  • Influenza Vaccines / administration & dosage*
  • Influenza Vaccines / immunology*
  • Influenza, Human / diagnosis
  • Influenza, Human / epidemiology*
  • Influenza, Human / prevention & control*
  • Influenza, Human / virology
  • Logistic Models
  • Male
  • Middle Aged
  • Primary Health Care
  • Reverse Transcriptase Polymerase Chain Reaction
  • Scotland / epidemiology
  • Seasons
  • Sentinel Surveillance
  • Sequence Analysis, DNA
  • Time Factors
  • Treatment Outcome
  • Vaccination / statistics & numerical data
  • Vaccines, Inactivated / administration & dosage
  • Vaccines, Inactivated / immunology
  • Young Adult

Substances

  • Influenza Vaccines
  • Vaccines, Inactivated