The effect of prophylactic anti-asthma drugs on PAF-induced airway hyperreactivity

Jpn J Pharmacol. 1989 Oct;51(2):151-60. doi: 10.1254/jjp.51.151.

Abstract

Intravenous injection of platelet activating factor (PAF) in anesthetized guinea pigs induces non-selective airway hyperreactivity. This response to PAF was reduced in a dose-dependent manner by systemic administration of established prophylactic anti-asthma drugs (ketotifen, cromoglycate, aminophylline and glucocorticosteroids) and by competitive antagonists of PAF. These inhibitory effects could not be accounted for by antagonism of histamine (H1), serotonin or peptidoleukotrienes receptors; parasympatholytic activity; cyclo-oxygenase or lipoxygenase inhibition; mast cell stabilization; or bronchodilatation. Infusion or injection of PAF to induce airway hyperreactivity in the guinea pig may provide a prospective test for prophylactic anti-asthma drugs.

MeSH terms

  • Animals
  • Asthma / physiopathology
  • Asthma / prevention & control*
  • Cyclooxygenase Inhibitors
  • Guinea Pigs
  • Histamine H1 Antagonists / pharmacology
  • In Vitro Techniques
  • Infusions, Intravenous
  • Lipoxygenase Inhibitors
  • Lung / drug effects
  • Lung / physiology
  • Male
  • Mast Cells / drug effects
  • Platelet Activating Factor / pharmacology*
  • Respiratory Function Tests
  • Respiratory System / drug effects*
  • Serotonin Antagonists / pharmacology

Substances

  • Cyclooxygenase Inhibitors
  • Histamine H1 Antagonists
  • Lipoxygenase Inhibitors
  • Platelet Activating Factor
  • Serotonin Antagonists