Abstract
This study is the first case report of the treatment of methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis using therapeutic drug monitoring of the serum and wound exudate concentrations of linezolid in a renal dysfunction patient. In the present study, the serum trough concentration of linezolid was maintained between 2 and 7 μg/mL. Therapeutic drug monitoring dosage adjustments may be especially useful in patients with renal dysfunction and severe MRSA infection.
MeSH terms
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Acetamides / administration & dosage
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Acetamides / adverse effects
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Acetamides / therapeutic use*
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Aged
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Cardiac Surgical Procedures / adverse effects
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Humans
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Linezolid
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Male
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Mediastinitis / drug therapy*
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Mediastinitis / epidemiology
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Methicillin-Resistant Staphylococcus aureus*
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Oxazolidinones / administration & dosage
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Oxazolidinones / adverse effects
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Oxazolidinones / therapeutic use*
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Postoperative Complications / microbiology*
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Renal Insufficiency / epidemiology
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Staphylococcal Infections / drug therapy
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Thrombocytopenia / chemically induced*
Substances
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Acetamides
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Oxazolidinones
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Linezolid