Hostile takeover: glioma stem cells recruit TAMs to support tumor progression

Yu Shi; Yi-fang Ping; Xia Zhang; Xiu-wu Bian

doi:10.1016/j.stem.2015.02.008

Hostile takeover: glioma stem cells recruit TAMs to support tumor progression

Cell Stem Cell. 2015 Mar 5;16(3):219-20. doi: 10.1016/j.stem.2015.02.008.

Authors

Yu Shi¹, Yi-fang Ping¹, Xia Zhang¹, Xiu-wu Bian²

Affiliations

¹ Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; Key Laboratory of Tumor Immunopathology of Ministry of Education of China, Third Military Medical University, Chongqing 400038, China.
² Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; Key Laboratory of Tumor Immunopathology of Ministry of Education of China, Third Military Medical University, Chongqing 400038, China. Electronic address: [email protected].

PMID: 25748928
DOI: 10.1016/j.stem.2015.02.008

Abstract

The dynamic interaction between cancer cells and immune cells is a critical concern for developing effective tumor immunotherapies. In a recent issue of Nature Cell Biology, Zhou et al. (2015) report that glioma stem cells secrete Periostin (POSTN), which recruits tumor-associated macrophages (TAMs) and supports the tumor-promoting M2 subtype.

Publication types

Comment

MeSH terms

Animals
Brain Neoplasms / metabolism*
Brain Neoplasms / pathology*
Cell Adhesion Molecules / metabolism*
Female
Glioblastoma / metabolism*
Glioblastoma / pathology*
Humans
Macrophages / metabolism*
Neoplastic Stem Cells / metabolism*

Substances

Cell Adhesion Molecules