From respiratory sensitization to food allergy: Anaphylactic reaction after ingestion of mushrooms (Agaricus bisporus)

Marta F Gabriel; Purificación González-Delgado; Idoia Postigo; Javier Fernández; Victor Soriano; Begoña Cueva; Jorge Martínez

doi:10.1016/j.mmcr.2015.02.003

From respiratory sensitization to food allergy: Anaphylactic reaction after ingestion of mushrooms (Agaricus bisporus)

Med Mycol Case Rep. 2015 Feb 24:8:14-6. doi: 10.1016/j.mmcr.2015.02.003. eCollection 2015 Jun.

Authors

Marta F Gabriel¹, Purificación González-Delgado², Idoia Postigo¹, Javier Fernández³, Victor Soriano², Begoña Cueva², Jorge Martínez¹

Affiliations

¹ Department of Immunology, Microbiology and Parasitology, Faculty of Pharmacy, Laboratory of Parasitology and Immunoallergy, Center for Research Laskaray, University of the Basque Country, Paseo Universidad, 6, 01006 Vitoria, Álava, Spain.
² Allergy Section, University General Hospital of Alicante, Calle Pintor Baeza s/n, 03010 Alicante, Spain.
³ Allergy Section, University General Hospital of Alicante, Calle Pintor Baeza s/n, 03010 Alicante, Spain ; Department of Medicine, Faculty of Medicine, University Miguel Hernández, Alicante-Valencia Road, 03550 San Joan, Alicante, Spain.

Abstract

We report a case of a 38-year-old mold-allergic patient who developed episodes of generalized urticaria and systemic anaphylactic shock immediately after ingesting button mushrooms. A manganese-dependent superoxide dismutase (MnSOD) and a NADP-dependent mannitol dehydrogenase (MtDH) from Agaricus bisporus mushroom were identified as patient-specific IgE-binding proteins. Cross-reactivity between A. bisporus MnSOD and mold aeroallergens was confirmed. We conclude that prior sensitization to mold aeroallergens might explain severe food reactions to cross-reacting homologs mushroom proteins.

Keywords: Agaricus bisporus; Anaphylaxis; Cross-reactivity; Food allergy; Mold allergy.