An OXA-48-producing Escherichia coli isolated from a Danish patient with no hospitalization abroad

Infect Dis (Lond). 2015 Aug;47(8):593-5. doi: 10.3109/23744235.2015.1019920. Epub 2015 Mar 9.

Abstract

Carbapenemase-producing organisms are disseminating globally and are now emerging as a worrying threat in Scandinavia. Before August 2013, OXA-48-producing organisms had not been detected in Danish patients. Here we report the isolation of an ST746 OXA-48-producing Escherichia coli with the plasmid pOXA-48a carrying the blaOXA-48 gene isolated from a Danish patient without history of hospitalization abroad. The patient reported tourist travel to Egypt and Turkey. The potential acquisition of carbapenemase-producing organisms by ingestion of contaminated food is discussed.

Keywords: Enterobacteriaceae; OXA-48; Travel-associated spread; carbapenem resistance.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Denmark
  • Drug Resistance, Bacterial / genetics
  • Egypt
  • Escherichia coli / enzymology
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification*
  • Escherichia coli Infections / microbiology*
  • Escherichia coli Proteins / biosynthesis*
  • Female
  • Genome, Bacterial
  • Hospitalization
  • Humans
  • Microbial Sensitivity Tests
  • Middle Aged
  • Plasmids
  • Sequence Analysis, DNA
  • Travel
  • Turkey
  • beta-Lactamases / biosynthesis*

Substances

  • Escherichia coli Proteins
  • beta-Lactamases
  • beta-lactamase OXA-48, E coli