Combined medico-surgical strategy for invasive sino-orbito-cerebral breakthrough fungal infection with Hormographiella aspergillata in an acute leukaemia patient

Mycoses. 2015 May;58(5):308-12. doi: 10.1111/myc.12305. Epub 2015 Mar 6.

Abstract

Hormographiella aspergillata is a rare causative agent of invasive filamentous breakthrough infection, mostly arising after echinocandin exposure. We report a neutropenic patient who developed a severe sino-orbito-cerebral H. aspergillata infection while receiving empirical caspofungin, successfully controlled by an aggressive strategy associating surgical debridement and combined high-dose regimen of antifungal drugs.

Keywords: Hormographiella aspergillata; acute myeloid leukaemia; allogeneic haematopoietic stem cell transplantation; basidiomycosis.

Publication types

  • Case Reports

MeSH terms

  • Agaricales / isolation & purification*
  • Antifungal Agents / therapeutic use*
  • Brain / microbiology
  • Brain / pathology
  • Caspofungin
  • Central Nervous System Fungal Infections / drug therapy*
  • Central Nervous System Fungal Infections / microbiology
  • Central Nervous System Fungal Infections / surgery*
  • Combined Modality Therapy
  • Debridement
  • Drug Resistance, Fungal
  • Echinocandins / therapeutic use
  • Fatal Outcome
  • Humans
  • Leukemia, Myeloid, Acute / complications*
  • Lipopeptides
  • Male
  • Molecular Sequence Data
  • Neutropenia / complications*
  • Young Adult

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Caspofungin

Associated data

  • GENBANK/AB097562
  • GENBANK/AF345819