Abstract
A diastereoselective Pd-catalyzed intramolecular cyclopropanation of alkenes with unstabilized allylic tosylhydrazones was developed. This methodology provides an efficient entry toward synthesis of the bicyclo[3.1.0] hexane system with an exo-double bond, and sets the basis for future elaboration of more complex polycyclic motifs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemistry*
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Bridged Bicyclo Compounds / chemical synthesis
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Bridged Bicyclo Compounds / chemistry
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Catalysis
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Cyclopentanes / chemical synthesis*
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Cyclopentanes / chemistry*
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Hydrazones / chemistry*
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Molecular Structure
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Organometallic Compounds / chemistry*
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Palladium / chemistry
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Stereoisomerism
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Tosyl Compounds / chemistry*
Substances
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Alkenes
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Bridged Bicyclo Compounds
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Cyclopentanes
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Hydrazones
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Organometallic Compounds
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Tosyl Compounds
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bicyclo(3.1.0)hexane
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Palladium