Survival and prognostic indicators of Budd-Chiari syndrome: a systematic review of 79 studies

Expert Rev Gastroenterol Hepatol. 2015 Jun;9(6):865-75. doi: 10.1586/17474124.2015.1024224. Epub 2015 Mar 10.

Abstract

This paper aimed to systematically review the survival of Budd-Chiari syndrome and to identify the most robust prognostic predictors. Overall, 79 studies were included. According to the treatment modalities, the median 1-, 5- and 10-year survival rate was 93, 83 and 73% after interventional radiological treatment; 81, 75 and 72.5% after surgery other than liver transplantation; 82.5, 70.2 and 66.5% after liver transplantation and 68.1, 44.4% and unavailable after medical therapy alone. According to the publication years, the median 1-, 5- and 10-year survival rate was 68.6, 44.4% and unavailable before 1990; 75.1, 69.5 and 57% during the year 1991-1995; 77, 69.6 and 65.6% during the year 1996-2000; 86.5, 74 and 63.5% during the year 2001-2005 and 90, 82.5 and 72% after 2006. Bilirubin, creatinine and ascites were more frequently identified as significant prognostic factors in univariate analyses. But their statistical significance was less frequently achieved in multivariate analyses.

Keywords: hepatic vein; hepatic venous outflow obstruction; inferior vena cava; predict; prognosis.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Budd-Chiari Syndrome / diagnosis
  • Budd-Chiari Syndrome / mortality
  • Budd-Chiari Syndrome / therapy*
  • Humans
  • Multivariate Analysis
  • Predictive Value of Tests
  • Risk Factors
  • Survival Analysis
  • Survival Rate
  • Time Factors
  • Treatment Outcome