Abstract
Doxorubicin-loaded nanogels with multiresponsive properties are prepared using hyperbranched polyglycerol as a biocompatible scaffold. The nanogels are synthesized in a single step combining free-radical polymerization and a mild nanoprecipitation technique. The nanogels respond to different biological stimuli such as low pH and reductive environments, resulting in a more efficient cell proliferation inhibition in A549 cells.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / administration & dosage*
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology*
-
Biocompatible Materials / administration & dosage
-
Biocompatible Materials / chemical synthesis
-
Biocompatible Materials / chemistry
-
Biocompatible Materials / pharmacology
-
Cell Line, Tumor
-
Cell Proliferation / drug effects
-
Dose-Response Relationship, Drug
-
Doxorubicin / administration & dosage*
-
Doxorubicin / chemistry
-
Doxorubicin / pharmacology
-
Drug Screening Assays, Antitumor
-
Glycerol / chemistry*
-
Humans
-
Molecular Structure
-
Nanogels
-
Polyethylene Glycols / administration & dosage*
-
Polyethylene Glycols / chemical synthesis
-
Polyethylene Glycols / chemistry
-
Polyethylene Glycols / pharmacology*
-
Polyethyleneimine / administration & dosage*
-
Polyethyleneimine / chemical synthesis
-
Polyethyleneimine / chemistry
-
Polyethyleneimine / pharmacology*
-
Polymers / chemistry*
-
Structure-Activity Relationship
Substances
-
Antineoplastic Agents
-
Biocompatible Materials
-
Nanogels
-
Polymers
-
polyethylene glycol polyethyleneimine nanogel
-
polyglycerol
-
Polyethylene Glycols
-
Doxorubicin
-
Polyethyleneimine
-
Glycerol