Microscopic polyangiitis associated with primary biliary cirrhosis, Sjogren's syndrome and Hashimoto's thyroiditis

Saudi J Kidney Dis Transpl. 2015 Mar;26(2):359-62. doi: 10.4103/1319-2442.152515.

Abstract

The association between microscopic polyangiitis (MPA) and primary biliary cirrhosis (PBC) has seldom been reported. We describe here a patient who presented with sensorimotor neuropathy along with hypothyroidism, renal failure and liver dysfunction. Detection of antinuclear antibodies at a titer of 1/800, anti-SSA, anti-SSB, anti-GP210, anti-microsomial and p-ANCA anti-myeloperoxydase antibodies along with renal, salivary and liver biopsy led to a diagnosis of MPA associated with PBC, Sjogren's syndrome and Hashimoto's thyroiditis.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Antinuclear / blood
  • Biomarkers / blood
  • Biopsy
  • Female
  • Hashimoto Disease / blood
  • Hashimoto Disease / complications*
  • Hashimoto Disease / diagnosis
  • Hashimoto Disease / drug therapy
  • Hashimoto Disease / immunology
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Liver Cirrhosis, Biliary / blood
  • Liver Cirrhosis, Biliary / complications*
  • Liver Cirrhosis, Biliary / diagnosis
  • Liver Cirrhosis, Biliary / drug therapy
  • Liver Cirrhosis, Biliary / immunology
  • Microscopic Polyangiitis / blood
  • Microscopic Polyangiitis / complications*
  • Microscopic Polyangiitis / diagnosis
  • Microscopic Polyangiitis / drug therapy
  • Microscopic Polyangiitis / immunology
  • Middle Aged
  • Predictive Value of Tests
  • Renal Insufficiency / etiology
  • Sjogren's Syndrome / blood
  • Sjogren's Syndrome / complications*
  • Sjogren's Syndrome / diagnosis
  • Sjogren's Syndrome / drug therapy
  • Sjogren's Syndrome / immunology
  • Steroids / therapeutic use
  • Treatment Outcome

Substances

  • Antibodies, Antinuclear
  • Biomarkers
  • Immunosuppressive Agents
  • Steroids