PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity

Matthew A Kappes; Kay S Faaberg

doi:10.1016/j.virol.2015.02.012

PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity

Virology. 2015 May:479-480:475-86. doi: 10.1016/j.virol.2015.02.012. Epub 2015 Mar 7.

Authors

Matthew A Kappes¹, Kay S Faaberg²

Affiliations

¹ Virus and Prion Research Unit, USDA-ARS-National Animal Disease Center, Ames, IA, USA.
² Virus and Prion Research Unit, USDA-ARS-National Animal Disease Center, Ames, IA, USA. Electronic address: [email protected].

Abstract

Porcine reproductive and respiratory disease virus (PRRSV) has the intrinsic ability to adapt and evolve. After 25 years of study, this persistent pathogen has continued to frustrate efforts to eliminate infection of herds through vaccination or other elimination strategies. The purpose of this review is to summarize the research on the virion structure, replication and recombination properties of PRRSV that have led to the extraordinary phenotype and genotype diversity that exists worldwide.

Keywords: Arterivirus; Heteroclite; Porcine reproductive and respiratory syndrome virus; Recombination; Replication; Subgenomic RNA.

Published by Elsevier Inc.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Genetic Variation*
Genotype
Phenotype
Porcine respiratory and reproductive syndrome virus / genetics
Porcine respiratory and reproductive syndrome virus / physiology*
Porcine respiratory and reproductive syndrome virus / ultrastructure*
Recombination, Genetic*
Virion / ultrastructure
Virus Replication*