The paper deals with the NMR spectra obtained using preparations of five different human biological body fluids. Characteristic metabolite signals of blood, urine, tears, saliva, and sweat spectra have been determined and classified. The biological body fluid samples were used for search and identification of biomarkers of cardiovascular disease. Absolute functional biomarkers for diseases such as coronary heart disease (CHD) have not been recognized even in the case acute myocardial infarction. A hypothesis explaining reasons of lack of such markers has been formulated. The results of comparative analysis of blood and urine samples from humans and some laboratory animals are given. Identify and analyze signals of metabolites of pathogenic microflora and their dynamics in the urine from patients with urogenital diseases have been determined and analyzed and characteristic biomarkers have been recognized.
V rabote predstavleny IaMR-spektry preparatov piati razlichnykh biologicheskikh zhidkosteĭ cheloveka. Opredeleny i klassifitsirovany signaly metabolitov, kharakternye dlia spektrov krovi, mochi, slezy, sliuny i pota. Byla predpriniata popytka vydelit' biomarkery nekotorykh serdechnososudistykh zabolevaniĭ v biozhidkostiakh patsientov. Absoliutnykh biomarkerov dlia funktsional'nykh zabolevaniĭ, takikh kak ishemicheskaia bolezn' serdtsa (IBS), dazhe v sluchae ee ostroĭ formy – infarkta miokarda, ne vyiavleno. Sformulirovana gipoteza, ob"iasniaiushchaia prichinu étogo. Predstavleny rezul'taty sravnitel'nogo analiza obraztsov krovi i mochi cheloveka i nekotorykh laboratornykh zhivotnykh. Opredeleny i proanalizirovany signaly metabolitov patogennoĭ mikroflory i ikh dinamika v moche pri nekotorykh zabolevaniiakh mochepolovoĭ sistemy. Vyiavleny kharakternye biomarkery.
Keywords: NMR; biological fluids; biomarkers.