Abstract
Recent functional studies have unveiled the significant role chromatin topology plays in gene regulation. Several lines of evidence suggest genes access necessary factors for transcription by forming chromatin loops. A clearer picture of the players involved in chromatin organization, including lncRNA, is emerging.
Keywords:
chromatin contact; chromatin loops; eRNA; enhancer; gene regulation; lncRNA; multigene complex; promoter; topologically associating domain; transcription.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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CCCTC-Binding Factor
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Cell Cycle Proteins / metabolism
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Chromatin / metabolism*
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Chromosomal Proteins, Non-Histone / metabolism
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Cohesins
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Enhancer Elements, Genetic
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Gene Expression Regulation*
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Humans
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RNA, Long Noncoding / metabolism*
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Repressor Proteins / metabolism
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Transcription Initiation, Genetic
Substances
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CCCTC-Binding Factor
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CTCF protein, human
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Cell Cycle Proteins
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Chromatin
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Chromosomal Proteins, Non-Histone
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RNA, Long Noncoding
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Repressor Proteins