Abstract
Atrial natriuretic peptide (ANP) and sodium nitroprusside have potent vasodilator effects on the noradrenaline-precontracted isolated rabbit aorta. A distinct elevation of cyclic GMP in the aortic tissue was observed after both vasodilators. In contrast to sodium nitroprusside, ANP-(5-28) induced a dose-dependent cyclic GMP extrusion from the tissue into the medium. Thus, release of cyclic GMP appears to be specific for activation of particulate guanylate cyclase and provides a mechanism in addition to synthesis and degradation by which the cells can regulate their internal concentrations of cyclic GMP.
MeSH terms
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Animals
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Aorta, Thoracic / drug effects
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Aorta, Thoracic / metabolism
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Atrial Natriuretic Factor / pharmacology*
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Chinchilla
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Cyclic AMP / metabolism*
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Female
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Ferricyanides / pharmacology*
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Guanylate Cyclase / metabolism
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In Vitro Techniques
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Muscle Relaxation / drug effects
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Muscle, Smooth, Vascular / drug effects
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Muscle, Smooth, Vascular / metabolism*
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Nitroprusside / pharmacology*
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Norepinephrine / pharmacology
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Peptide Fragments / pharmacology
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Rabbits
Substances
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Ferricyanides
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Peptide Fragments
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Nitroprusside
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Atrial Natriuretic Factor
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atrial natriuretic factor (5-28)
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Cyclic AMP
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Guanylate Cyclase
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Norepinephrine