Altered expression of metabotropic glutamate receptor 1 alpha after acute diffuse brain injury: Effect of the competitive antagonist 1-aminoindan-1, 5-dicarboxylic acid

Fei Cao; Mantao Chen; Gu Li; Ke Ye; Xin Huang; Xiujue Zheng

doi:10.3969/j.issn.1673-5374.2012.02.007

Altered expression of metabotropic glutamate receptor 1 alpha after acute diffuse brain injury: Effect of the competitive antagonist 1-aminoindan-1, 5-dicarboxylic acid

Neural Regen Res. 2012 Jan 15;7(2):119-24. doi: 10.3969/j.issn.1673-5374.2012.02.007.

Authors

Fei Cao¹, Mantao Chen¹, Gu Li¹, Ke Ye¹, Xin Huang¹, Xiujue Zheng¹

Affiliation

¹ Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China ; Institute of Brain Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.

PMID: 25767486
PMCID: PMC4354126
DOI: 10.3969/j.issn.1673-5374.2012.02.007

Abstract

The diffuse brain injury model was conducted in Sprague-Dawley rats, according to Marmarou's free-fall attack. The water content in brain tissue, expression of metabotropic glutamate receptor 1α mRNA and protein were significantly increased after injury, reached a peak at 24 hours, and then gradually decreased. After treatment with the competitive antagonist of metabotropic glutamate receptor 1α, (RS)-1-aminoindan-1, 5-dicarboxylic acid, the water content of brain tissues decreased between 12-72 hours after injury, and neurological behaviors improved at 2 weeks. These experimental findings suggest that the 1-aminoindan-1, 5-dicarboxylic acid may result in marked neuroprotection against diffuse brain injury.

Keywords: 1-aminoindan-1, 5-dicarboxylic acid; animal model; diffuse brain injury; in vivo; metabotropic glutamate receptor 1 alpha.