Human Multidrug Resistance 1 gene polymorphisms and Idiopathic Pulmonary Fibrosis

Background: For the first time we tested an association between the human multidrug resistance gene 1 (MDR1) polymorphisms (SNPs) and idiopathic pulmonary fibrosis (IPF). Several MDR1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics.

Materials and methods: We genotyped three MDR1 polymorphisms of 48 IPF patients and 100 control subjects with Italian origins.

Results: No evidence of association was detected.

Conclusion: There are 50 known MDR1 SNPs, and their role is explored in terms of the effectiveness of drug therapy. We consider our small-scale preliminary study as a starting point for further research.