Expression profiling of adult acute lymphoblastic leukemia identifies a BCR-ABL1-like subgroup characterized by high non-response and relapse rates

Haematologica. 2015 Jul;100(7):e261-4. doi: 10.3324/haematol.2014.117424. Epub 2015 Mar 13.
No abstract available

Keywords: B-cell precursor acute lymphoblastic leukemia; BCR-ABL-like acute lymphoblastic leukemia; expression profiling; outcome.

Publication types

  • Clinical Trial
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antineoplastic Agents / therapeutic use*
  • Fusion Proteins, bcr-abl / genetics*
  • Fusion Proteins, bcr-abl / metabolism
  • Gene Expression
  • Gene Expression Profiling
  • Hematopoietic Stem Cell Transplantation*
  • Histone-Lysine N-Methyltransferase / genetics
  • Histone-Lysine N-Methyltransferase / metabolism
  • Humans
  • Ikaros Transcription Factor / genetics
  • Ikaros Transcription Factor / metabolism
  • Imatinib Mesylate / therapeutic use*
  • Middle Aged
  • Mutation
  • Myeloid-Lymphoid Leukemia Protein / genetics
  • Myeloid-Lymphoid Leukemia Protein / metabolism
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Protein Kinase Inhibitors / therapeutic use
  • Recurrence
  • Remission Induction
  • Survival Analysis
  • Transplantation, Homologous

Substances

  • Antineoplastic Agents
  • BCR-ABL1 fusion protein, human
  • IKZF1 protein, human
  • KMT2A protein, human
  • Protein Kinase Inhibitors
  • Ikaros Transcription Factor
  • Myeloid-Lymphoid Leukemia Protein
  • Imatinib Mesylate
  • Histone-Lysine N-Methyltransferase
  • Fusion Proteins, bcr-abl