Importance of early absolute lymphocyte count after allogeneic stem cell transplantation: a retrospective study

Transplant Proc. 2015 Mar;47(2):511-6. doi: 10.1016/j.transproceed.2014.11.042.

Abstract

Introduction: Early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation (HSCT) is related to the prevention of serious infections and the clearing of residual tumor cells.

Methods: We analyzed the absolute lymphocyte count at 20 (D+20) and 30 (D+30) days after HSCT in 100 patients with malignant hematologic diseases and correlated with the risk of transplant-related mortality, overall survival (OS), disease-free survival (DFS), nonrelapsed mortality (NRM), and risk of infection.

Results: Patients presenting with lymphocyte counts of <300 × 103/μL on D+30 have a 3.76 times greater risk of death in <100 days. Over a medium follow-up of 20 months OS, DFS, and NRM were similar between the groups.

Conclusion: In our group of patients delayed lymphocyte recovery after HSCT was a predictor of early death post-HSCT.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Disease-Free Survival
  • Female
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Leukemia / blood*
  • Leukemia / mortality
  • Leukemia / therapy*
  • Lymphocyte Count*
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes / blood*
  • Myelodysplastic Syndromes / mortality
  • Myelodysplastic Syndromes / therapy*
  • Predictive Value of Tests
  • Retrospective Studies
  • Survival Rate
  • Time Factors
  • Transplantation, Homologous
  • Treatment Outcome
  • Young Adult