Kaennacowanols A-C, three new xanthones and their cytotoxicity from the roots of Garcinia cowa

Sutin Kaennakam; Pongpun Siripong; Santi Tip-Pyang

doi:10.1016/j.fitote.2015.03.008

Kaennacowanols A-C, three new xanthones and their cytotoxicity from the roots of Garcinia cowa

Fitoterapia. 2015 Apr:102:171-6. doi: 10.1016/j.fitote.2015.03.008. Epub 2015 Mar 11.

Authors

Sutin Kaennakam¹, Pongpun Siripong², Santi Tip-Pyang³

Affiliations

¹ Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
² Natural Products Research Section, Research Division, National Cancer Institute, Bangkok 10400, Thailand.
³ Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: [email protected].

PMID: 25771120
DOI: 10.1016/j.fitote.2015.03.008

Abstract

Three new xanthones, named kaennacowanols A-C (1-3), along with nineteen known xanthones were isolated from the roots of Garcinia cowa Roxb. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against KB and HeLa cell lines. Compounds 17 and 22 showed good cytotoxicity against KB cell with IC50 values of 7.97 and 9.10μM, respectively. On the other hand, compound 15 showed good cytotoxicity against HeLa cell with IC50 value of 9.34μM.

Keywords: Clusiaceae; Cytotoxicity; Garcinia cowa; Kaennacowanols A–C; Xanthone.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line
Garcinia / chemistry*
Humans
Molecular Structure
Plant Extracts / chemistry*
Plant Roots / chemistry*
Xanthones / chemistry*
Xanthones / isolation & purification

Substances

Plant Extracts
Xanthones
kaennacowanol A
kaennacowanol B
kaennacowanol C