Hybridization-induced Ag(I) dissociation from an immobilization-free and label-free hairpin DNA: toward a novel electronic monitoring platform

Analyst. 2015 Apr 21;140(8):2634-7. doi: 10.1039/c5an00046g. Epub 2015 Mar 16.

Abstract

A novel silver ion (Ag(+))-assisted hairpin DNA through C-Ag(+)-C coordination chemistry was designed for immobilization-free and label-free electrochemical monitoring of human immunodeficiency virus (HIV) DNA on a negatively charged indium-tin oxide electrode, based on hybridization-induced dissociation of silver ions from the hairpin DNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Biosensing Techniques / instrumentation*
  • DNA, Viral / analysis*
  • DNA, Viral / chemistry*
  • DNA, Viral / genetics
  • Electrochemistry
  • Electrodes
  • HIV
  • Humans
  • Immobilized Nucleic Acids / chemistry*
  • Inverted Repeat Sequences*
  • Nucleic Acid Hybridization
  • Silver / chemistry*
  • Tin Compounds / chemistry

Substances

  • DNA, Viral
  • Immobilized Nucleic Acids
  • Tin Compounds
  • Silver
  • indium tin oxide