Palladium-catalyzed dicarbonylative synthesis of tetracycle quinazolinones

Org Biomol Chem. 2015 Apr 21;13(15):4422-5. doi: 10.1039/c5ob00368g.

Abstract

An interesting procedure for the synthesis of isoindolo[1,2-b]quinazolin-10(12H)-ones has been developed. Starting from commercially available 2-bromoanilines and 2-bromobenzyl amines, with the assistance of a palladium catalyst, the desired products were isolated in good yields. Notably, this procedure proceeded in a highly selective manner; two molecules of CO were incorporated into the substrates selectively.