Abstract
The interest in pyridopyrimidine cores for pharmaceutical products makes this scaffold a highly useful building block for organic chemistry. These derivatives have found applications in various areas of medicine such as anticancer, CNS, fungicidal, antiviral, anti-inflammatory, antimicrobial, and antibacterial therapies. This review mainly focuses on the progress achieved since 2004 in the chemistry and biological activity of pyridopyrimidines.
Keywords:
Heterocycles; Pharmacological activities; Pyridopyrimidine; Synthesis.
Copyright © 2015 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Central Nervous System Agents / chemistry
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Central Nervous System Agents / pharmacology*
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Drug Design
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Heterocyclic Compounds / chemistry
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Heterocyclic Compounds / pharmacology*
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Humans
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Pyrimidines / chemistry
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Pyrimidines / pharmacology*
Substances
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Anti-Infective Agents
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Antiviral Agents
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Central Nervous System Agents
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Heterocyclic Compounds
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Pyrimidines